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Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

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2020-01
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Elsevier
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Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with 'peroxiporin' activity (AQP3, AQP8, AQP9). Here, we exploit different organelle-targeted H2O2-sensitive probes to show that also AQP11 efficiently conduits H2O2. Unlike other peroxiporins, AQP11 is localized in the endoplasmic reticulum (ER), accumulating partly in mitochondrial-associated ER membranes (MAM). Its downregulation severely perturbs the flux of H2O2 through the ER, but not through the mitochondrial or plasma membranes. These properties make AQP11 a potential regulator of ER redox homeostasis and signaling.
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Aquaporins, Peroxiporins, Hydrogen peroxide, Membrane permeability, Endoplasmic reticulum, Redox homeostasis
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Bestetti, S., Galli, M., Sorrentino, I., Pinton, P., Rimessi, A., Sitia, R., & Medraño-Fernandez, I. (2020). Human Aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane. Redox biology, 28, 101326.