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Do pregnancy-induced brain changes reverse? The brain of a mother six years after parturition

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Groupes
dc.contributor.authorMartinez Garcia, Magdalena Teresa
dc.contributor.authorPaternina-Die, María
dc.contributor.authorBarba-Müller, Erika
dc.contributor.authorMartín De Blas, Daniel
dc.contributor.authorBeumala, Laura
dc.contributor.authorCortizo, Romina
dc.contributor.authorPozzobon, Cristina
dc.contributor.authorMarcos Vidal, Luis
dc.contributor.authorFernández-Pena, Alberto
dc.contributor.authorPicado, Marisol
dc.contributor.authorBelmonte-Padilla, Elena
dc.contributor.authorMassó-Rodriguez, Anna
dc.contributor.authorBallesteros, Agustín
dc.contributor.authorDesco Menéndez, Manuel
dc.contributor.authorVilarroya, Óscar
dc.contributor.authorHoekzema, Elseline
dc.contributor.authorCarmona Cañabate, Susana
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2021-09-23T10:19:16Z
dc.date.available2021-09-23T10:19:16Z
dc.date.issued2021-02
dc.descriptionThis article belongs to the Special Issue Neural and Epigenetic Factors in Parenting: Individual Differences and Dyadic Processes.en
dc.description.abstractNeuroimaging researchers commonly assume that the brain of a mother is comparable to that of a nulliparous woman. However, pregnancy leads to pronounced gray matter volume reductions in the mother’s brain, which have been associated with maternal attachment towards the baby. Beyond two years postpartum, no study has explored whether these brain changes are maintained or instead return to pre-pregnancy levels. The present study tested whether gray matter volume reductions detected in primiparous women are still present six years after parturition. Using data from a unique, prospective neuroimaging study, we compared the gray matter volume of 25 primiparous and 22 nulliparous women across three sessions: before conception (n = 25/22), during the first months of postpartum (n = 25/21), and at six years after parturition (n = 7/5). We found that most of the pregnancy-induced gray matter volume reductions persist six years after parturition (classifying women as having been pregnant or not with 91.67% of total accuracy). We also found that brain changes at six years postpartum are associated with measures of mother-to-infant attachment. These findings open the possibility that pregnancy-induced brain changes are permanent and encourage neuroimaging studies to routinely include pregnancy-related information as a relevant demographic variable.en
dc.description.sponsorshipThis work was supported by Ministerio de Ciencia, Innovación y Universidades project RTI2018-093952-B-100 and by Instituto de Salud Carlos III projects CP16/00096 and PI17/00064, and co-funded by European Regional Development Fund (ERDF), "A way of making Europe." The project exAScale ProgramIng models for extreme Data procEssing (ASPIDE) has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 801091. M.M.-G. and S.C. were funded by Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III, Predoctorales de Formación en Investigación en Salud (PFIS), contract FI18/00255 and Miguel Servet Type I research contract CP16/00096, respectively) and co-funded by European Social Fund "Investing in your future." M.P.-D. was supported by Consejería de Educación e Investigación, Comunidad de Madrid, co-funded by European Social Fund "Investing in your future" (PEJD-2018-PRE/BMD-9401). The project leading to these results has received funding from "la Caixa" Foundation under the project code LCF/PR/HR19/52160001. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).en
dc.format.extent14
dc.identifier.bibliographicCitationMartínez-García, M., Paternina-Die, M., Barba-Müller, E., Martín De Blas, D., Beumala, L., Cortizo, R., Pozzobon, C., Marcos-Vidal, L., Fernández-Pena, A., Picado, M., Belmonte-Padilla, E., Massó-Rodriguez, A., Ballesteros, A., Desco, M., Vilarroya, S., Hoekzema, E. & Carmona, S. (2021). Do Pregnancy-Induced Brain Changes Reverse? The Brain of a Mother Six Years after Parturition. Brain Sciences, 11(2), 168.en
dc.identifier.doihttps://doi.org/10.3390/brainsci11020168
dc.identifier.issn2076-3425
dc.identifier.publicationfirstpage168
dc.identifier.publicationissue2
dc.identifier.publicationtitleBrian Scienceen
dc.identifier.publicationvolume11
dc.identifier.urihttps://hdl.handle.net/10016/33312
dc.identifier.uxxiAR/0000028265
dc.language.isoeng
dc.publisherMDPI
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/GA-801091
dc.rights© 2021 by the authors.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaAeronáuticaes
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaMedicinaes
dc.subject.ecienciaPsicologíaes
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaternal Brainen
dc.subject.otherNeuroplasticityen
dc.subject.otherPostpartumen
dc.subject.otherPregnancyen
dc.titleDo pregnancy-induced brain changes reverse? The brain of a mother six years after parturitionen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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