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Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Groupes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédicaes
dc.contributor.authorHadar, R.
dc.contributor.authorBikovski, L.
dc.contributor.authorSoto Montenegro, Mª Luisa
dc.contributor.authorSchimke, J.
dc.contributor.authorMaier, P.
dc.contributor.authorEwing, S.
dc.contributor.authorVoget, M.
dc.contributor.authorWieske, Franziska
dc.contributor.authorGoetz, T.
dc.contributor.authorDesco Menéndez, Manuel
dc.contributor.authorHamani, Clement
dc.contributor.authorPascau González-Garzón, Javier
dc.contributor.authorWeiner, Ina
dc.contributor.authorWinter, Christine
dc.date.accessioned2021-06-21T10:37:28Z
dc.date.available2021-06-21T10:37:28Z
dc.date.issued2017-04-04
dc.description.abstractThe notion that schizophrenia is a neurodevelopmental disorder in which neuropathologies evolve gradually over the developmental course indicates a potential therapeutic window during which pathophysiological processes may be modified to halt disease progression or reduce its severity. Here we used a neurodevelopmental maternal immune stimulation (MIS) rat model of schizophrenia to test whether early targeted modulatory intervention would affect schizophrenia’s neurodevelopmental course. We applied deep brain stimulation (DBS) or sham stimulation to the medial prefrontal cortex (mPFC) of adolescent MIS rats and respective controls, and investigated its behavioral, biochemical, brain-structural and -metabolic effects in adulthood. We found that mPFC-DBS successfully prevented the emergence of deficits in sensorimotor gating, attentional selectivity and executive function in adulthood, as well as the enlargement of lateral ventricle volumes and mal-development of dopaminergic and serotonergic transmission. These data suggest that the mPFC may be a valuable target for effective preventive treatments. This may have significant translational value, suggesting that targeting the mPFC before the onset of psychosis via less invasive neuromodulation approaches may be a viable preventive strategy.en
dc.description.sponsorshipWe thank Renate Winter, Doris Zschaber and Roselies Pickert for excellent technical assistance. This research was conducted under the EraNet Neuron framework (DBS_F20rat) and supported by the BMBF, Germany (B01EW1103, 01EE1403A), Fundación Mapfre, Comunidad de Madrid and the Ministry of Economy and Competitiveness ISCIII-FIS grants (PI14/00860, CPII/00005) co-financed by ERDF (FEDER) Funds from the European Commission, ‘A way of making Europe’, Spain (PI14/00860, CPII/00005, MV1500002), the CSO-MOH, Israel (3-8580) and the Canadian Institutes of Health Research, Canada (CIHR, 110068), and co-financed by the DFG, Germany (WI 2140/1-1/2; WI 2140/2-1).es
dc.description.statusPublicadoes
dc.format.extent8
dc.identifier.bibliographicCitationMolecular Psychiatry (2018) 23(4), 943–951.en
dc.identifier.doihttps://doi.org/10.1038/mp.2017.52
dc.identifier.issn1359-4184
dc.identifier.publicationfirstpage943
dc.identifier.publicationissue4
dc.identifier.publicationlastpage951
dc.identifier.publicationtitleMOLECULAR PSYCHIATRYen
dc.identifier.publicationvolume23
dc.identifier.urihttps://hdl.handle.net/10016/32900
dc.identifier.uxxiAR/0000021234
dc.language.isoengen
dc.publisherSpringer Natureen
dc.relation.projectIDGobierno de España. PI14/00860es
dc.relation.projectIDGobierno de España. CPII/00005es
dc.rights© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved 1359-4184/18en
dc.rights.accessRightsopen accessen
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaMedicinaes
dc.subject.otherDeep brain stimulationen
dc.subject.otherAnimal disease modelsen
dc.subject.otherPsychotic disordersen
dc.subject.otherSchizophreniaen
dc.subject.otherNeurotransmitter agentsen
dc.subject.otherSensory gatingen
dc.subject.otherDopamineen
dc.subject.otherBrainen
dc.subject.otherNeuroscienceen
dc.titleEarly neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophreniaen
dc.typeresearch article*
dc.type.hasVersionAM*
dspace.entity.typePublication
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