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Local and distant functional connectivity patterns in adults with Attention Deficit Hyperactivity Disorder (ADHD)

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2018
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2018-10-10
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Attention Deficit Hyperactivity Disorder (ADHD) is said to be one of the most controversial and common neurodevelopmental Brain disorders. However, there is no potential diagnostic biomarker found yet. Recently, the neuroimaging group have conducted a cross-sectional study in which by using graph theory approach, local and distant functional connectivity patterns were compared between ADHD and Normal Developing (ND) children. They found that children with ADHD manifest increased local connectivity in multiple brain regions. Results suggested an immature functional state in some brain networks and were in line with the view of ADHD as a disorder in accordance to the maturational deviation model. The main goal of present study is to depict the functional maturational level of the Brain in adults with ADHD based on local and distant connectivity by comparing cross-sectionally ADHD and control samples. Results found are consistent with a decrease in local Functional Connectivity (FC) in multiple brain networks, which is translated into reduced integration. Moreover, a negative correlation between symptom severity and FC has been found within main nodes of a specific network supporting the lack of integration in it.
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Attention Deficit Hyperactivity Disorder (ADHD), Brain disorders, Biochemical markers, Functional Connectivity (FC), Neuroimaging
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