Publication: Fully 4D reconstruction of dynamic SPECT images based on the estimation of spatiotemporal basis coefficients directly from projection measurements
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ISSN: 1082-3654
ISBN: 978-1-4244-2714-7
Publication date
2008-10
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IEEE
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Abstract
Quantitative kinetic analysis of dynamic cardiac SPECT data provides unique information that can enable improved discrimination between healthy and diseased tissue, compared to static imaging.
Conventional kinetic parameter estimation is based on the reconstruction of a dynamic sequence of 3D images from complete
projections and the fitting of the compartmental kinetic models to
time-activity curves generated by overlaying regions of interest on
the reconstructed sequence. The problem with this approach is
that, due to the gantry motion involved and the changes in the
distribution of radiopharmaceutical during the acquisition, the
projection data at different angles come from ditTerent tracer
distributions resulting in inconsistent projections. Images
reconstructed from these inconsistent projections can contain
artifacts that lead to bias in the estimated kinetic parameters.
In this work we present a fully 4D reconstruction algorithm for
dynamic SPECT in a parallel ray geometry. The method is based
on modeling the spatial and temporal distribution of the
radiotracer inside the field of view with spatial tri-linear B-spline and 4 piecewise quadratic temporal B-spline basis functions The algorithm was tested on a dynamic 99mTc-teboroxime cardiac SPECT/CT canine study.
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Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 Oct. 2008
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Bibliographic citation
2008 IEEE Nuclear Science Symposium Conference Record, Oct. 2008, p. 4604 - 4607