Publication: Use of IBASPM atlas-based automatic segmentation toolbox in pathological brains: effect of template selection
Loading...
Identifiers
ISSN: 1082-3654
ISBN: 978-1-4244-2714-7
Publication date
2008-10
Defense date
Advisors
Tutors
Journal Title
Journal ISSN
Volume Title
Publisher
IEEE
Abstract
IBASPM software is an atlas-based method for
automatic segmentation of brain structures, available as a freeware toolbox for the SPM package. To test the influence of the atlas when segmenting normal and pathologic brains, manual segmentation of the caudate nucleus head was compared to automatic segmentations using four different atlases: the default MNI AAL atlas; a customized atlas created from a combined
sample of patients (n=20) and controls (n=18); and a customized atlas obtained separately for each group. Maximum average ratio of overlapping voxels (dice overlap) between manual and
automatic segmentation was 71 o~ for controls and 52% for patients. In both groups, overlap ratios were better when using the customized atlases, instead of the standard MNI AAL atlas.
Accuracy of the method was biased between left and right hemispheres, and also between groups, individual variability being higher in patients than in controls. Volumetric measurements using the customized atlases were also more
accurate than using the MNI AAL atlas. Volume data were closer to manual segmentation values than dice overlap ratio (average differences ranging from 22.7°~ for MNI AAL atlas to 10.1 for
customized atlas of patients and controls combined). Results suggests a low overaU performance of IBASPM as an automatic
segmentation method for the head of the caudate nucleus.
Because of the biases observed, the use of this method for analyzing caudate nucleus in patients presenting anatomical abnormalities should be cautiously carried out.
Description
Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 Oct. 2008
Keywords
Bibliographic citation
2008 IEEE Nuclear Science Symposium Conference Record, oct. 2008, p. 4270-4272