Publication: Towards high performance small animal positron emission tomography
Loading...
Identifiers
Publication date
2002-07
Defense date
Advisors
Tutors
Journal Title
Journal ISSN
Volume Title
Publisher
IEEE
Impact
Export
Abstract
During the last decade increasingly sophisticated positron emission tomography (PET) scanners have been developed for imaging small laboratory animals. These systems often exhibit performance characteristics, e.g. spatial resolution, substantially better than contemporary human
PET scanners and are often the first systems to demonstrate new technologies, e. g. avalanche photodiodebased detector modules. Despite these advances, spatial resolution, sensitivity, resolution uniformity and other
performance parameters must continue to be improved if accurate general purpose imaging is to be carried out in the most popular research subject, the mouse. Moreover.
as these improvements occur, methods must also be devised to minimize the resolution-degrading effects of positron range, the distance a positron travels from the
decaying nucleus before encountering and mutually anll1hllattng an electron. Range effects are particularly important for compounds labeled with "non-traditional"
positron-emitters such as 1-124 or Tc-94m.
In order to illustrate the complex interplay of issues that must be addressed when contemplating such improvements, we describe how we have approached high performance PET imaging in the design and construction
of ATLAS (Advanced Technology Laboratory Animal Scanner), a small animal PET scanner now entering servIce at the National Institutes of Health (NIH) in Bethesda, Md.
Description
Proceeding of: 2002 IEEE Symposium International on Biomedical Imaging, Washington, D.C., USA, July 7-10, 2002
Keywords
Bibliographic citation
2002 IEEE International Symposium on Biomedical Imaging Proceedings, Jul. 2002, p. 369-372