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Fluorescence multi-scale endoscopy and its applications in the study and diagnosis of gastro-intestinal diseases: set-up design and software implementation

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Groupes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédicaes
dc.contributor.authorGómez García, Pablo Aurelioes
dc.contributor.authorArranz, Aliciaes
dc.contributor.authorFresno, Manueles
dc.contributor.authorDesco Menéndez, Manueles
dc.contributor.authorMahmood, Umar
dc.contributor.authorVaquero López, Juan Josées
dc.contributor.authorRipoll Lorenzo, Jorgees
dc.date.accessioned2015-06-25T09:17:13Z
dc.date.available2015-06-25T09:17:13Z
dc.date.issued2015
dc.descriptionProceedings of: IPA 2015 / SPIE Biophotonics South America. Rio de Janeiro, Brazil, 22-26 May, 2015en
dc.description.abstractEndoscopy is frequently used in the diagnosis of several gastro-intestinal pathologies as Crohn disease, ulcerative colitis or colorectal cancer. It has great potential as a non-invasive screening technique capable of detecting suspicious alterations in the intestinal mucosa, such as inflammatory processes. However, these early lesions usually cannot be detected with conventional endoscopes, due to lack of cellular detail and the absence of specific markers. Due to this lack of specificity, the development of new endoscopy technologies, which are able to show microscopic changes in the mucosa structure, are necessary. We here present a confocal endomicroscope, which in combination with a wide field fluorescence endoscope offers fast and specific macroscopic information through the use of activatable probes and a detailed analysis at cellular level of the possible altered tissue areas. This multi-modal and multi-scale imaging module, compatible with commercial endoscopes, combines near-infrared fluorescence (NIRF) measurements (enabling specific imaging of markers of disease and prognosis) and confocal endomicroscopy making use of a fiber bundle, providing a cellular level resolution. The system will be used in animal models exhibiting gastro-intestinal diseases in order to analyze the use of potential diagnostic markers in colorectal cancer. In this work, we present in detail the set-up design and the software implementation in order to obtain simultaneous RGB/NIRF measurements and short confocal scanning times.en
dc.description.sponsorshipThe authors acknowledge support from EC FP7 IMI project PREDICT-TB, the EC FP7 CIG grant HIGH-THROUGHPUT TOMO, the Spanish MINECO project grant FIS2013-41802-R MESO-IMAGING, and TOPUS S2013/MIT-3024 project from the regional government of Madriden
dc.description.statusPublicadoes
dc.format.extent10
dc.format.mimetypeapplication/pdf
dc.identifier.bibliographicCitationKurachi, C., Svanberg, K. & Tromberg, B. J. (eds.) (2015). Biophotonics South America. Proceedings SPIE, vol . 9531, 9531111. Society of Photo-Optical Instrumentation Engineersen
dc.identifier.doihttp://dx.doi.org/10.1117/12.2189960
dc.identifier.isbn9781628416961
dc.identifier.publicationtitleBiophotonics South America. Proceedings SPIEen
dc.identifier.publicationvolume9531
dc.identifier.urihttps://hdl.handle.net/10016/21187
dc.identifier.uxxiCC/0000023802
dc.language.isoengen
dc.publisherSpie- The International Society For Optical Engineeringen
dc.relation.eventdate22-26 May, 2015en
dc.relation.eventplaceRio de Janeiro, Brazilen
dc.relation.eventtitleIPA 2015 / SPIE Biophotonics South Americaen
dc.relation.projectIDComunidad de Madrid. S2013/MIT-3024/TOPUSes
dc.relation.projectIDGobierno de España. FIS2013-41802-Res
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/333632en
dc.rights© 2015. SPIE. Society of Photo-Optical Instrumentation Engineers.en
dc.rights.accessRightsopen accesses
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.otherEndoscopyen
dc.subject.otherEndomicroscopyen
dc.subject.otherFiber bundleen
dc.subject.otherFluorescenceen
dc.subject.otherScanen
dc.subject.otherSoftwareen
dc.subject.otherCell imagingen
dc.titleFluorescence multi-scale endoscopy and its applications in the study and diagnosis of gastro-intestinal diseases: set-up design and software implementationen
dc.typeconference paper*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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