Characterization in a humanized context of a rare disease: dyskeratosis congenita

Acitores Balboa, David

Publication:
Characterization in a humanized context of a rare disease: dyskeratosis congenita

dc.contributor.advisor	García Diez, Marta
dc.contributor.author	Acitores Balboa, David
dc.contributor.departamento	UC3M. Departamento de Bioingeniería e Ingeniería Aeroespacial	es
dc.date.accessioned	2016-07-26T15:44:00Z
dc.date.available	2016-07-26T15:44:00Z
dc.date.issued	2015
dc.date.submitted	2015-07-06
dc.description.abstract	The experimental work of the final degree project was dedicated to apply the knowledge acquired of tissue engineering and regenerative medicine, which are branches of biomedical engineering, focusing on the study of rare skin diseases. The project was developed at CIEMAT (Centro de Investigaciones MedioAmbientales y Tecnológicas) organization and with support of biomedical laboratories of Universidad Carlos III de Madrid. The project was controlled by Doctor Marta García Díez. The research was focused in the characterization of Dyskeratosis Congenita, which present different symtomes, including skin defects, due to lack of dyskerin protein. To perform this task In vitro and In vivo experiments are done for the characterization of diseased skin. In order to obtain a precise result bioengineered skin, histology, antibody detection and other methods are used. The main objective of this work is the generation and validation of an In vitro skin-humanized modelof DC (Dyskeratosis Congenita) of cells patients, recreating the cutaneous phenotype of this disease and then assess therapeutic approaches based on genetically modificated DC cells by lentiviral vectors coding for GSE-24.2.	es
dc.description.degree	Ingeniería Biomédica	es
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/10016/23427
dc.language.iso	eng	es
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 España	*
dc.rights.accessRights	open access	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/es/	*
dc.subject.eciencia	Biología y Biomedicina	es
dc.subject.other	Tissue engineering	es
dc.subject.other	Regenerative medicine	es
dc.subject.other	Biomedical engineering	es
dc.subject.other	Rare diseases	es
dc.subject.other	Skin	es
dc.subject.other	Dyskeratosis congenita	en
dc.title	Characterization in a humanized context of a rare disease: dyskeratosis congenita	es
dc.type	bachelor thesis	*
dspace.entity.type	Publication