Publication:
Potentiation of acute morphine-induced analgesia measured by a thermal test in bone cancer-bearing mice

Simple item page
dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Tissue Engineering and Regenerative Medicine (TERMeG)es
dc.contributor.authorGonzález Rodríguez, Saraes
dc.contributor.authorGonzález Llamez, Saraes
dc.contributor.authorHidalgo, Agustínes
dc.contributor.authorBaamonde, Anaes
dc.contributor.authorMenéndez, Luises
dc.date.accessioned2015-10-05T10:25:49Z
dc.date.available2015-10-05T10:25:49Z
dc.date.issued2012-06
dc.description.abstractAgonists of mu-opioid receptors are currently used in the management of cancer pain. However, several data suggest that the analgesic effect of morphine can diminish during the development of experimental tumors. By using a thermal test, we have studied whether the analgesic effect evoked by morphine is altered in mice bearing two painful bone tumors. The analgesic effect evoked by systemic morphine remained unaltered after the intratibial inoculation of B16-F10 melanoma cells and was potentiated after the inoculation of NCTC 2472 osteosarcoma cells. Although the number of spinal mu-opioid receptors measured by western blot studies was not augmented in osteosarcoma-bearing mice, the analgesia evoked by intrathecal (i.t.) morphine was also enhanced. The analgesic response produced by the spinal administration of the Gi/o protein activator mastoparan was amplified, whereas the analgesic response evoked by the i.t. administration of the N-type calcium channel blocker ?-conotoxin remained unaltered. The efficacy of the GIRK channel blocker tertiapin-Q to antagonize the analgesic effect produced by a maximal dose of morphine was also increased in osteosarcoma-bearing mice. Our results seem to indicate that the analgesic effect of morphine on thermal nociception can be enhanced in response to the development of particular bone tumors in mice, being this potentiation probably related to a greater efficacy of the transduction system driven by Gi/o proteins and GIRK channels.en
dc.description.sponsorshipGrants were provided by MEC-FEDER (SAF2009-10567). SL received a grant from CIBER of Enfermedades Raras of the Instituto de Salud Carlos III (ISCIII). The Instituto Universitario de Oncología is supported by Obra Social Cajastur-Asturias, Spain.en
dc.format.mimetypeapplication/pdf
dc.identifier.bibliographicCitationFundamental & clinical pharmacology (2012) vol. 26, no. 3, pp. 363-372
dc.identifier.doi10.1111/j.1472-8206.2010.00921.x
dc.identifier.issn0767-3981
dc.identifier.publicationfirstpage363
dc.identifier.publicationissue3
dc.identifier.publicationlastpage372
dc.identifier.publicationtitleFundamental & clinical pharmacologyen
dc.identifier.publicationvolume26
dc.identifier.urihttps://hdl.handle.net/10016/21661
dc.identifier.uxxiAR/0000013997
dc.language.isoengen
dc.publisherJohn Wiley & Sons Ltden
dc.relation.projectIDGobierno de España MEC-FEDER SAF2009-10567es
dc.relation.publisherversionhttp://dx.doi.org/10.1111/j.1472-8206.2010.00921.x
dc.rights© 2011 The Authors Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique
dc.rights.accessRightsopen accessen
dc.subject.ecienciaMedicinaes
dc.subject.otherB16-F10en
dc.subject.otherBone canceren
dc.subject.otherHot plateen
dc.subject.otherMiceen
dc.subject.otherMorphineen
dc.subject.otherNCTC 2472en
dc.subject.otherOpioid receptor agonistsen
dc.subject.otherMurine modelen
dc.subject.otherRat modelen
dc.subject.otherNeurochemical changesen
dc.subject.otherPotassium channelsen
dc.subject.otherSystemic morphineen
dc.subject.otherInflammatory painen
dc.subject.otherSpinal corden
dc.subject.otherHyperalgesiaen
dc.titlePotentiation of acute morphine-induced analgesia measured by a thermal test in bone cancer-bearing miceen
dc.typeresearch article*
dc.type.hasVersionAM*
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
potentation_gonzalez-rodriguez_2012_FCP_ps.pdf
Size:
254.83 KB
Format:
Adobe Portable Document Format
Download
Collections
DBIAB - TERMEG - Journal Articles